Interaction Between Mirtazapine and Clonidine. ABSTRACT & COMMENTARY Source: Abo-Zena RA, et al. Hypertensive urgency induced by an interaction of mirtazapine and clonidine. Summary. Drug interactions are reported among people who take Clonidine and Mirtazapine together. This study is created by eHealthMe based on reports of 333 people who take Clonidine and Mirtazapine from FDA, and is updated regularly. Mirtazapine is a new antidepressant with a tetracyclic chemical structure that is not related to selective serotonin reuptake inhibitors, tricyclic antidepressants, or monoamine oxidase inhibitors. Mirtazapine, sold under the brand name Remeron among others, is an antidepressant primarily used to treat depression. Its. A case report published in 2000 noted an instance in which mirtazapine counteracted the action of clonidine, causing a dangerous rise in blood pressure. Clonidine, sold as the brand name Catapres among others, is a medication used to treat high blood pressure, attention deficit hyperactivity disorder, drug withdrawal (alcohol, opioids, or smoking), menopausal flushing, diarrhea, and certain pain conditions. WebMD provides information about interactions between Remeron Oral and tricyclic-compounds-mirtazapine-clonidine. Learn about drug interactions between clonidine-chlorthalidone oral and mirtazapine oral and use the RxList drug interaction checker to check drug combinations. Compare Clonidine vs. Mirtazapine, which is better for uses like: Anxiety and Insomnia. Compare head-to-head ratings, side effects, warnings, dosages, interactions and patient reviews. Patients rated Clonidine 4.3/5 over Mirtazapine 3.2/5 in overall satisfaction. La clonidine passe dans le lait maternel, il est donc préférable d'éviter d'allaiter en cas de traitement. Cependant en cas d'allaitement, une surveillance du nouveau-né est conseillée. Cependant en cas d'allaitement, une surveillance du nouveau-né est conseillée. This appendix provides a table of drug interactions with medications used in other conditions. The British National Formulary (BNF) includes a summary appendix dedicated to drug interactions.